Chronic kidney disease is consider to be a major health issue which affecting high percent of population worldwide. This study attempted to determine the effects of chronic kidney disease on the function of thyroid gland by measuring its hormones levels . There were 70 subjects included in this study their age between 20 to 70 years divided into two groups, patients and control groups each one contain 35 persons. Blood was obtained from the all subjects for measuring the levels of thyroid hormones . There was increasing in the incidence of chronic kidney disease in the fifties of age as the results of this study revealed. The levels of thyroid hormones recorded significantly P≤0.05 decreasing in patients with chronic kidney disease when compared with healthy persons. For conclude, chronic kidney disease leads to significant changes in the levels of thyroid hormones that need to be carefully interpreted in these patients.