The crystal structure of the 1 : 1 donor-acceptor complex of 3,5-dinitrobenzoic acid and 4-(N,Ndimethylamino) benzoic acid contains the uncommon 0-H 0 hydrogen-bonded carboxy homo-Paper 31035541

Molecules of 1,3,5-tricyanobenzene are networked with C-H...N hydrogen bonds into a symmetrical hexagonal pattern in the crystal structure of the 1 : 1 complex formed by the compound with hexamethylbenzene. structure of pure 3 itself but in general, layering of a planar aromatic hydrocarbon is difficult and the crystal structure of pure 3 is exceptional.15 Retrieval of all hexamethylbenzene containing structures from the Cambridge Structural Data-base16 (1992 release, version 5 , 102589 entries) yielded ten hits (no metal atom) but in many of these, the molecules of 3 are arranged in a herringbone or quasi-herringbone fashion. 15

Objectives:The present investigation was aimed to study the antidiabetic and antihyperlipidemic potential of Abelmoschus esculentus peel and seed powder (AEPP and AESP) in streptozotocin (STZ)-induced diabetic rats.Materials and Methods:Acute toxicity of AEPP and AESP was studied in rats at 2000 mg/kg dose and diabetes was induced in rats by administration of STZ (60 mg/kg, i.p.). After 14 days of blood glucose stabilization, diabetic rats received AEPP, AESP, and glibenclamide up to 28 days. The blood samples were collected on day 28 to estimate the hemoglobin (Hb), glycosylated hemoglobin (HbA1c), serum glutamate-pyruvate transferase (SGPT), total protein (TP), and lipid profile levels.Results:In acute toxicity study, AESP and AESP did not show any toxicity or death up to a dose of 2000 mg/kg. Therefore, to assess the antidiabetic action, one by fifth and one by tenth dose of both powders were selected. Administration of AEPP and AESP at 100 and 200 mg/kg dose in diabetic rats showed significant (P < 0.001) reduction in blood glucose level and increase in body weight than diabetic control rats. A significant (P < 0.001) increased level of Hb, TP, and decreased level of HbA1c, SGPT were observed after the treatment of both doses of AEPP and AESP. Also, elevated lipid profile levels returned to near normal in diabetic rats after the administration of AEPP and AESP, 100 and 200 mg/kg dose, compared to diabetic control rats.Conclusion:The present study results, first time, support the antidiabetic and antihyperlipidemic potential of A. esculentus peel and seed powder in diabetic rats.

Weak C=N.-CI interactions may be used to design linear molecular tapes.The construction of molecular ensembles, utilising the directional characteristics of intermolecular forces, is one of the key elements of contemporary supramolecular chemistry. 1 Linear or zig-zag arrays of flat molecules have been described by Lehn2 and by Whitesides3 who has referred to such arrays as 'molecular tapes'. Tapes, such as those found in the crystal structures of molecular complexes of substituted aminopyrimidines or melamines and substituted barbituric acids,2.3 have been designed using the directional properties of strong N-H.e.0 bonds.4.5 The underlying rationale is that these bonds are so specific and important in crystal packing that molecular assembly can proceed in a regular, anticipated manner. In this communication, we show that molecular tapes may be constructed with forces that are far weaker than conventional hydrogen bonds. Short C=N...Cl contacts were first postulated by Hassel6 and later reviewed by Britton.7 We have shown that N...Cl distances, D , in crystals range between 3.00 and 3.45 A and that GN...Cl angles, 8, vary between 80 and 18V.8 This CkN..-Cl contact arises owing to the polarisability of C1, and the crystal packing of several simple chloro cyano compounds, for example the polymorphs of 4-chlorobenzonitrile, may be understood on the basis of a secondary motif built up via these CkN*-CP+ interactions. Accordingly, it was felt that substituted 2,3-dicyano-5,6-dichlorobenzenes would be good candidates for the formation of a CkN...Cl mediated molecular tape such as is shown in Fig. 1.

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