Novel Coronavirus (SARS-CoV-2) first broke out in China and speeded globally. With the considerable number of Covid-19 infections and deaths, the situation has brought up major public health and governance concerns. This research study is conducted to understand if there is any association between blood group and Covid-19 disease severity. Study is conducted in Life care diagnostic and research center, New road Pokhara. A total of 1050 people who underwent RT-PCR test at Life Care Diagnostic and identified positive are used as the sample to conduct this research study. Our findings reveal that Covid-19 severity is uncommon in people with blood group O and Rh negative whereas those with blood group AB and B types are found to be severely affected. We also have an impression that individuals with rhesus negative (Rh-negative) blood groups have higher resistance for Covid-19 infection and severity.