BACKGROUND:Pancytopenia is an important clinico-haematological entity encountered in our day to day clinical practice. It is defined as the reduction of all three formed elements of blood (erythrocytes, leucocytes and platelets) below the normal reference range leading to anaemia, leucopoenia and thrombocytopenia. OBJECTIVES: To study the etiologies, to assess the haematological and bone marrow changes and to correlate these changes with automated cell counter parameters in various causes of pancytopenia. Assessment of B12 and folic acid levels in cases of pancytopenia due to megaloblastic anemia.
A bone marrow examination at the end of induction chemotherapy provides information whether patient has achieved remission with regeneration of cells or still has residual leukemia. If the patient is in remission, maintenance treatment is started and if not more intensive chemotherapy or bone marrow transplantation may be embarked upon.
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