Blood pressure is affected by situational anxiety, such as the white coat effect. We hypothesised that blood pressure would also be affected by anticipation of a blood test. Volunteer subjects were recruited on the campus of Birmingham University. Subjects were randomly assigned to intervention and control groups. After a period of rest, three seated blood pressure measurements were taken at 1-min intervals using an electronic sphygmomanometer. Between the second and third measurements subjects in the intervention group were told that a blood test would be carried out after the last measurement. No blood test was carried out. Three blood pressure measurements were made in all 213 randomised subjects. Analysis was by intentionto-treat. In the control group mean systolic and diastolic

No abstract

Background: Garlic is naturally occurring sulphur containing dietary agent belong to Allium family. Members of this family i.e. Garlic, Onions are found to have beneficial effect on atherosclerosis and ischemic heart diseases in both experimental animals and in human beings. Objective: To compare the potency of garlic as antihyperlipidemic and antiplatelet and antithrombotic between its watery and alcoholic extract for their effects. Methods: 25 guinea pigs were fed cholesterol (0.5g/kg body weight) for an initial period of 4 weeks. Cholesterol was then discontinued and the animals were divided into 3 groups. Group-I (n=7) was fed with stock diet and was taken as control. Group-II (n=9) was given 1ml of watery extract and Group-III (n=9) was fed with 1ml of alcoholic extract of garlic with normal diet daily for 4 weeks. The garlic content of both the extract was 2 gm/ml by wt/vol. Fasting blood samples were collected at the end 4 weeks and finally at the end of the study i.e.8 weeks for estimation of serum cholesterol, serum triglyceride, LDC-C, HDL-C, VLDL-C,atherogenic index and platelet adhesiveness index. Bleeding time and clotting time were also detected in all the 3 groups.Results: In the present study, the watery and alcoholic extract of garlic shows significant hypolipidemic activity as they reduced significantly serum cholesterol, serum triglyceride, LDC-C, VLDL-C and atheriogenic index in hyperlipidemic guinea pigs (p<0.01) compared to control. The significant rise in HDL-C was observed in group II but not in group III animals. On comparison between two extracts, watery extract of garlic was more potent hypolipidemic agent, compared to alcoholic extract. Both extract significantly reduces platelet adhesiveness and bleeding time. But between two extract the watery extract was found more potent anti-thrombotic agent as it showed significant decrease in platelet adhesiveness (P<0.01). BT was significantly increased in group II compared to group I and III. Conclusion: It can be concluded that watery extract of Allium Sativum is more potent hypolipidemic and antiplatelet, and anti-thrombotic agent.

Original Research Article Breast cancer, one of the most common malignancies affecting women worldwide. Treatment of breast cancer by Anthracycline group of drug which are the most effective anticancer treatments ever develops. However, cardio toxicity is a well-recognized side effect of anthracycline treatment and can cause heart failure. The aim of the study was to Assessment of Parasympathetic function test in breast cancer patients after chemotherapy treatment. We enroll 125 symptomatic breast cancer patients (Before and after chemotherapy treatment) who treated with anthracycline group of drug. To assess the Parasympathetic functions CAN Win device was used. The result showed that E/I ratio, Valsalva manoeuvre is highly significantly decreased in breast cancer patients after chemotherapy treatment, but 30:15 Ratio is Non-significantly (NS) decreased in breast cancer patients after chemotherapy treatment.

Original Research Article Breast cancer, one of the most common malignancies affecting woman worldwide. Treatment of breast cancer by Anthracycline group of drug which are the most effective anticancer treatments ever develops. However, cardio toxicity is a well-recognized side effect of anthracycline treatment and can cause heart failure. The aim of the study was to Assessment of sympathetic function test in breast cancer patients after chemotherapy treatment. We enroll 125 symptomatic breast cancer patients (Before and after chemotherapy treatment) who treated with anthracycline group of drug. To assess the Sympathetic functions CANWin device was used. The result showed that ΔSBP after standing is significantly increased while ΔDBP after SHP (SUSTAIN HAND GRIP TEST) significantly decreased in breast cancer patients after chemotherapy (Anthracycline) treatment.