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Introduction: Low back pain is a silent epidemic and a major health problem of modern society. WHO has labeled the first decade of the third millennium as decade of campaign against musculoskeletal disorders. Methodology: Prospective observational case series carried out with consecutive patients taking homeopathic treatment in primary care center. Subjects recruited in the age group of 18 to 60 years having chronic low back pain were assessed for pain with Numerical Pain rating Scale and disability with Oswestry Low Back Pain Disability Questionnaire, over two years. Results: Oswestry scale as well as NPRS before and after where t-table value of 2.05 concludes effectiveness of treatment with significant improvement with individualized Homoeopathic medicine. Conclusion: Homeopathic medicines have potential to improve Low back pain by reducing pain and disability and can safely be employed as a comprehensive health care therapeutics.