Birt-Hogg-Dubé syndrome (BHD) is a rare autosomal dominant disease characterized by skin fibrofolliculomas, pulmonary cysts, spontaneous pneumothoraces, and renal cancers. Oncocytomas are benign epithelial tumors that are also rare. Recently, there have been a few case reports of BHD with a parotid oncocytoma that appears to have a BHD phenotype. Here we document the eighth known case and describe the magnetic resonance imaging features of the parotid oncocytoma, which mimicked Warthin's tumor. Radiologists should be aware of the association between these rare disorders.
We present a case of multifocal micronodular pneumocyte hyperplasia (MMPH), lymphangiomyomatosis (LAM) and angiomyolipoma (AML) in a 33-year-old woman with tuberous sclerosis complex referred to us during her first pregnancy. Computed tomography of the chest showed diffuse micronodules and cysts in both lungs. Compared to those before pregnancy, the number of micronodules increased evidently. We hypothesized the micronodules in both lungs were either LAM, MMPH, or a combination of the two. Bilateral renal AML also intensified. About one month after childbirth, LAM and renal AML decreased without treatment. Therefore, we observed that LAM and AML were affected by the pregnancy. To the best of our knowledge, this is the first case report regarding the reversible alteration of LAM without treatment.
In response to concerns about overuse and increasing radiation exposure of myocardial perfusion imaging, nuclear medicine societies have declared statements aimed at lowering its radiation dose and costs. Simultaneously, two vendors have launched novel SPECT scanners with solid-state semiconductor detectors. Discovery NM 530c and D-SPECT utilize the same cadmium zinc telluride (CZT) detectors with a different combination of high-sensitivity multi-pinhole or parallelhole collimator which focuses on the heart. The physical performance of those is dramatically higher than that of conventional Anger cameras; however, 2 CZT cameras are inherently different. Although 99m Tc-labeled myocardial perfusion tracers might not be ideal agents, estimation of absolute myocardial blood flow or myocardial flow reserve (MFR) using dynamic CZT SPECT is a challenging subject and attracts a great deal of interest in the field. Thus, novel software which allows automatic calculation of MFR index with dynamic CZT SPECT is currently under development and validated in our institution. This technology will hold promise if the several issues can be solved through future studies.
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