Miyoshi myopathy is an autosomal recessive distal myopathy with predominant involvement of the posterior calf muscles attributed to mutations in the dysferlin gene. We report a 26-year-old male, born of nonconsanginous parentage. He noticed weakness and atrophy of leg muscles with inability to walk on his heels. The creatine kinase concentration was high. The electromyography showed myopathic pattern and the muscle biopsy disclosed dystrophic changes with absence of dysferlin. Miyoshi myopathy may be distinct among the hereditary distal myopathies. There are only few reported cases of Miyoshi myopathy in the world literature. In India only 12 cases were reported who had classical features of Miyoshi myopathy. Our's is a typical case of Miyoshi myopathy, with an affected twin sister as well. He also had “calf heads on a trophy sign” on physical examination, which is considered to be pathognomonic of this disease.
Acute puerperal uterine inversion is a rare but life threatening complication of third stage of labour. The incidence varies widely between 1 in 2000 to 1 in 50,000 deliveries, largely dependent upon the standard of management of the third stage of labour. Acute uterine inversion occurs within 24 hours delivery; subacute between 24 hours and 4 weeks of delivery and chronic uterine inversion after 4 weeks or in the non pregnant state. Cases of subacute and chronic uterine inversion require surgical management. [Int J Reprod Contracept Obstet Gynecol 2013; 2(3.000): 427-429
Female feticide is an extreme form of violence against women, the most active part is being played by the women themselves just for the mere want of a boy, mothers don't feel bad in strangulating their own daughters in their wombs. From decades of sex determination and female feticide is creating a statistical imbalance regarding the commonly expected 'male: female' birth ratio in India. This offense have been spreaded to the states in India like Punjab, Haryana, Delhi, Gujarat and Rajasthan, with the news of increasing number of female fetus being aborted from Orissa & Bangalore. The 2011 census has revealed a drastic fall in child sex ratio throughout the country. The decline in child sex ratio in India is guarded by the census figure, in 1991 the figure was 947 girls to 1000 boys, ten years later in 2001 it was about for 927 girl child to 1000 boys. In 2011 it further declined to 914 girl children to 1000 boys.
A 30 year old sixth gravida patient having five spontaneous abortions between fifth and sixth months of amenorrhea. Patient had an incompetent cervix, cervical cerclage was done at 14 weeks of gestation by Mc Donald's method. Pregnancy was uneventful for more than one month and patient reported back with complaints of bleeding per vaginum, and pain abdomen, cerclage was removed by duty doctor in emergency, but pains subsided. Ultrasound was done revealing low lying placenta reaching upto the os with 22 weeks live intrauterine pregnancy. Repeat transvaginal cervical cerclage was decided and done in similar manner. Patient was kept indoor on bed rest, tocolytics, antibiotics and progesterone support till the time of delivery. At 30 weeks pregnancy ultrasound revealed low amniotic fluid index (1.2) for which amino acid infusion was administered. Later on patient developed bleeding & leaking per vaginum with cervical dilatation, so immediate cesarean section decided and corticosteroid administered for fetal lung maturity, emergency cesarean section was done. In follow up mother and baby were absolutely healthy. The pregnancy outcome is significantly improved even after repeat cervical cerclage in same pregnancy and if there is a need for repeat cervical cerclage during same pregnancy it should be done to improve fetal salvage.
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