The therapeutic effect of expelling wind and relieving cough and asthma prescription on bronchial asthma with high immunoglobulin E (IgE) expression was studied based on high resolution CT (HRCT) images of intelligent enhancement algorithm. 90 patients with bronchial asthma were randomly divided into control group ( n = 45 ) and therapy group ( n = 45 ). The control group was given budesonide inhalation. The therapy group was treated with expelling wind and relieving cough and asthma prescription on the basis of the treatment in the control group. Both groups were given 1 month of treatment time. The scanned images were processed by image enhancement algorithm, and the image quality and distribution separation measurement (DSM) were used as image evaluation indicators. The bronchial wall thickness (WT), inner diameter (L), wall area (WA), and percentage of wall area (WA%) were used as quantitative indicators of airway remodeling. The changes of traditional Chinese medicine (TCM) score before and after treatment were recorded and analyzed. The changes of serum IgE indicators before and after treatment were recorded. Results: the image quality of HRCT image enhancement algorithm was better, and the DSM was 36.7 larger than that of the control group. It was found that after 1 month of treatment, the TCM symptom score of the therapy group was lower than that of the control group ( P < 0.05 ), and compared with the control group, the IgE level of the therapy group was also reduced. Meanwhile, compared with the control group, the WT of segmental bronchial wall in the therapy group decreased, and the WT of left apical bronchus was smaller than that in the control group ( P < 0.05 ), and the WT of subsegmental bronchus decreased significantly ( P < 0.05 ). The L of segmental bronchus and subsegmental bronchus in the therapy group was wider ( P < 0.05 ). The WA of segmental bronchus and subsegmental bronchus decreased, but there was no statistical significance ( P > 0.05 ). Compared with the control group, the WA percentage of segmental bronchus and the WA percentage of subsegmental bronchus in the therapy group were significantly lower ( P < 0.05 ). In conclusion, image enhancement algorithm can improve the HRCT image quality of patients with bronchial asthma, which is helpful to improve the diagnostic efficiency in clinical treatment. Expelling wind and relieving cough and asthma prescription has a better therapeutic effect on bronchial asthma with high IgE expression.