Building information modelling (BIM) is a set of technologies that aim to increase interorganisational and cross-disciplinary collaboration in the architecture, engineering, and construction (AEC) industries to promote productivity and the quality of design, construction, and maintenance stages of a building. Studies on BIM adoption in small and medium-sized enterprises (SMEs) have remained an under-represented area. It is necessary to understand the main challenges hindering the adoption of BIM in SMEs and to consider corresponding strategies that can be applied in order to obtain further understanding of BIM in SMEs. On the basis of literature review and interview, stakeholder-associated factors were identified from a network perspective, and the social network analysis (SNA) method was applied to determine the interconnections between the influencing factors and links in BIM adoption in SMEs. Eventually, 10 critical factors and 10 crucial links were selected and divided into six challenges. Corresponding strategies, including cultivating the BIM perception of SMEs, integrated project delivery, strengthening the legal environment for BIM adoption in SMEs, and developing native software and standards and cloud-based technology, were proposed to mitigate these challenges. The strategies may help practitioners gain an in-depth understanding of BIM adoption in SMEs from a stakeholder-oriented perspective.

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The green retrofitting of existing residential buildings is an important approach to realise the sustainable development of stock buildings. In addition to the new technologies and materials related to green retrofitting, the intention of residents toward the green retrofitting of existing residential buildings must be understood. However, the factors affecting such intentions are still unclear. Hence, this study refers to the extended theory of planed behaviour and constructs a theoretical model of the intention toward the green retrofitting of existing residential buildings. On the basis of the data from 507 questionnaires collected from eastern and western China, the theoretical model is tested via structural equation modelling (SEM). Multigroup SEM is used to analyse the differences in population characteristics and the intention of residents toward the green retrofitting of existing residential buildings in residential areas. Research results reveal the following: (1) the most important factors affecting residents’ intention toward green retrofitting are policy factors, followed by cognition of green retrofitting, behaviour, subjective norms, and perceived behavioural control; (2) policy factors not only directly affect residents’ intention toward green retrofitting but also indirectly affect their intention toward existing residential green retrofitting through perceived behavioural control; (3) residents’ cognition of green retrofitting exerts no significant direct impact on their intention toward green retrofitting, but it does indirectly affect their intention toward green retrofitting through behaviour and subjective norms; (4) behaviour, subjective norms, and perceived behavioural control have direct and significant influences on intention toward green retrofitting; (5) demographic characteristics (gender, age, monthly family income, education level, and occupation) and regional variables (east and west) present significant differences in different influence paths. The conclusion of the study provides a targeted path reference for the promotion of the green retrofitting of existing residential buildings.

In China, the demand for public infrastructure projects is high due to the acceleration of urbanization and the rapid growth of the economy in recent years. Infrastructures are mainly large scale, so local governments have difficulty in independently completing financing work. In this context, public sectors often seek cooperation from private sectors, in which public-private partnership (PPP) is increasingly common. Although numerous studies have concentrated on sustainable development, the unsustainability performances of infrastructures are often reported on various media. Furthermore, studies on the sustainability performances of PPP-type infrastructure (PTI) projects are few from the perspective of private sectors' behaviors. In this study, we adopted the modified theory of planned behavior and the structure equation model and conducted a questionnaire survey with 258 respondents for analyzing the sustainable behaviors of private sectors. Results indicated that behavioral attitude, perceived behavioral control, and subjective norm interact significantly. They have direct positive effects on behavioral intention and then indirectly influence actual behavior through this intention. Actual sustainable behaviors of private sectors have significantly positive effects on the sustainable development of cities. We offer theoretical and managerial implications for public and private sectors on the basis of the findings to ensure and promote the sustainability performances of PTI projects.

Receptor-interacting protein kinase 1 (RIPK1) contributes to a broad set of inflammations and necroptosis in human diseases, which also plays an important role in the pathogenesis of Alzheimer’s disease (AD). The inhibition of RIPK1 could be a novel strategy to improve cognitive function. SZM679, a highly specific RIPK1 inhibitor (K d,RIPK1 = 8.6 nM, K d,RIPK3 > 5000 nM), was developed by our group with superior high antinecroptotic activity (EC50 = 2 nM), and investigated to completely reverse the tumor necrosis factor-induced systemic inflammatory response syndrome. In a streptozocin-induced AD-like mouse model, behavioral tests showed that SZM679 apparently ameliorated learning and memory dysfunction. Nissl staining revealed that SZM679 improved neuronal loss. Moreover, the Tau hyperphosphorylation, neuroinflammation, and the RIPK1 phosphorylation level in the hippocampus and cortex were significantly decreased in the SZM679-treated group. Collectively, SZM679 represents a promising lead structure for the discovery of novel RIPK1 inhibitory anti-AD agents.