ABSTRACT. A nine-month-old domestic short haired cat was admitted with the history of acute vomiting, depression and shivering. Abdominal ultrasonography revealed minimum enlargement of the right uterine horn filled with anechoic fluid. On excretory urography, functionally and anatomically normal, enlarged left kidney was found, but right kidney was absent. It was preliminary diagnosed as hydrometra with right renal agenesis. Aiming at the correction of hydrometra, we performed ovariohysterectomy. During spaying, we found a missing segment of distal part of the right uterine horn and absence of ipsilateral kidney and ureter. Compressed uterine structure and segmental aplasia of right uterine horn were found in histopathological investigation. Taken together, it was diagnosed as a segmental aplasia of uterine horn with ipsilateral renal agenesis. KEY WORDS: feline, renal agenesis, uterine segmental aplasia.J. Vet. Med. Sci. 70(6): 641-643, 2008 A nine-month-old, intact female, domestic short haired cat was admitted with the history of acute vomiting, depression and shivering for three days. The rise of temperature (40°C) was recorded, and there was azotemia (BUN: 74.0 mg/dl, creatinine: 4.5 mg/dl) on the routine blood screening test. Abdominal radiography showed absence of the right kidney, while the left one was enlarged (3.2 × length of the 2nd lumbar vertebra). Incidentally, there was unilateral sacralization of the 7th lumbar vertebra with articulation between right transverse process and the ilium at same side. Abdominal ultrasonography demonstrated minimum enlargement of the right uterine horn (12.5 mm in diameter) filled with anechoic fluid. Excretory urography revealed the normal shape and opacification pattern of the left kidney meaning the normal physiological activities, however, the right kidney was absent (Fig. 1). In spite of unknown causes of azotemia, this patient was recovered through 2 days supportive treatment including fluid therapy and diuretics, and then received ovariohysterectomy under general anesthesia to prevent further deterioration of the uterine horn. Surprisingly, there were no the distal part of the right uterine horn, the right kidney and the right ureter during surgery (Fig. 2A). The remnant of the right uterine horn was tortuous and dilated with fluid, and was not connected to the body of the uterus. The left uterine horn was intact and there was a small notch as vestige at the body of uterus (Fig. 2B). Gross and histopathologic examination revealed that both ovaries, fallopian tubes and the left uterine horn were normal (Fig. 3A-C There is unilateral sacralization of the 7th lumbar vertebra with articulation between right transverse process and the ilium at same side (arrow).