BACKGROUND Anastomotic leak is an important cause of postoperative morbidity and mortality in patients who have undergone bowel anastomosis. The aim of the study is to know about the significance of various factors influencing anastomotic leak. MATERIALS AND METHODS A total of 68 patients who underwent small bowel anastomosis in our study period were followed up and grouped according to the occurrence of anastomotic leak into leak and non-leak groups. The common factors between the two groups were compared to know the significance of each factor in anastomotic leakage. RESULTS It has been found out that ASA Score ≥3, low serum total protein, low serum albumin, low haemoglobin, severe peritoneal contamination, perioperative fall in blood pressure and high mean duration of surgery were significantly associated with the occurrence of anastomotic leakage. CONCLUSION Adequate attention should be paid to the various preoperative, intraoperative and postoperative factors which influence anastomotic leakage in small bowel anastomosis in order to keep the morbidity and mortality to a bare minimum.