The end of the line: Structural studies demonstrate the consecutive formation of G‐quadruplexes in human single‐stranded telomeric‐overhang DNA. A higher‐order DNA G‐quadruplex structure was found to protect DNA double‐strand ends from being recognized as double‐strand breaks and to direct against nuclease hydrolysis, suggesting that the superhelix structure may provide protective “capping” for the telomere ends.
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