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Wheat is the main cereal crop in Egypt. The gap between production and consumption is about 60%. Research efforts are needed to reduce this gap, therefore; the objective of this work was to study the effect of three water regimes as irrigation at 45%, 60% and 70% depletion of the available soil moisture, and three nitrogen fertilization levels on two wheat varieties (Giza 168 and Giza 171).The field experiments were carried out at Bahry El-Methaq region, Alexandria Governorate, Egypt during the two successive winter seasons of 2015/2016 and 2016/2017. The experimental design of the study followed split split plot design (SSPD) with three replicates, keeping two bread wheat cultivars {Giza 168 and Giza 171 } as the main plots, irrigation regimes (irrigation at 45%, 60% and 70% depletion of the available soil moisture) as subplot, and the three fertilization levels as 100%, 80% and 60% from recommended fertilizer rates of nitrogen fertilization common applied as sub-subplot. The results showed that seasonal ET0 was 665.9 mm for the first season and 624.8 for the second season.

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