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Objective To determine the value of patient-reported symptoms in diagnosing endometriosis.Design A national case-control study.Setting Data from the UK General Practice Research Database for years 1992-2001.Sample A total of 5540 women aged 15-55 years, diagnosed with endometriosis, each matched to four controls without endometriosis.Methods Data were analysed to determine whether specific symptoms were highly indicative of endometriosis. Odds ratios for these symptoms were derived by conditional logistic regression analysis. . Women with endometriosis were also found to consult the doctor more frequently than the controls and were twice as likely to have time off work.Conclusions Specific symptoms and frequent medical consultation are associated with endometriosis and appear useful in the diagnosis. Endometriosis may coexist with or be misdiagnosed as pelvic inflammatory disease or IBS.

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