Significance PARP is an important target in the treatment of cancers, particularly in patients with breast, ovarian, or prostate cancer that have compromised homologous recombination repair (i.e., BRCA −/− ). This review about inhibitors of PARP (PARPi) is for readers interested in the development of next-generation drugs for the treatment of cancer, providing insights into structure–activity relationships, in vitro vs. in vivo potency, PARP trapping, and synthetic lethality.

For non-profit social agencies, new contract funding structures have increased their vulnerability. Collaboration is a strategy for dealing with reductions in the availability of funding and the pressures to ‘do more with less’ but there are few illustrations of how this might be achieved. The main body of literature devoted to creating models for collaboration was developed in the world of the new public administration and market models. Many of the less formal approaches consist of checklists and mock contracts that strive to account for variables that may affect collaborations. While valuable for focussing attention on key aspects, these approaches assume a static set of factors that predict successful collaborations. In this project, an alternative to these types of functional or instrumental methods of partnership development was created through a particular type of action research known as co-operative inquiry. Through the iterative stages of reflection and action, a new conceptualization of collaboration evolved and a subsequent model developed. The model is based on criteria derived from the experiences of the community members and accounts for the dialectical relationship of the individual agency and the collective non-profit sector. Through the process of the research, a transformation in thinking, purpose and practice occurred, resulting in a new metaphor for living and working in the community.

Zusammenfassung: Es wird über ein Symposium berichtet, das sich ausschließlich der Problematik "Harnenzyme" widmete. Auf dem Symposium mit 58 Teilnehmern aus 10 Ländern wurde in 39 Vorträgen der aktuelle Wissensstand der Harnenzymdiagnostik von der Grundlagenforschung bis zur klinischen Anwendbarkeit dargelegt und diskutiert. Der Bericht faßt die wesentlichen Punkte der Vorträge und Diskussionen zusammen. Urine enzymes in research and in the clinic Report on the Symposium of the Humboldt-Universität Berlin and the Bezirkskrankenhaus Frankfurt l O der Frankfurt/Oder, April 22-25, 1987Summary: The Symposium was dedicated exclusively to the subject of urine enzymes. Thirty nine lectures were given, in which 58 participants from 10 countries presented and discussed our present state of knowledge in the field of urine enzyme diagnosis, covering all aspects from fundamental research to its clinical application. This report summarizes the essential points of interest that arose from the lectures and discussions.Vortragende:

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In this presentation, the managing editors of GSA’s peer-reviewed journals will discuss how the editorial offices operate and their roles in the publishing process. The topics will include how to navigate the ScholarOne submission system, why it is important to read the Instructions to Authors, and how authors can work with the editorial offices to increase the visibility and impact of their published articles.