Introduction: The bibliographic review that is presented is the result of the research “Open Innovation and Knowledge Management” developed at the Universidad Distrital Francisco José de Caldas, during the year 2019. Objective: To demonstrate a Knowledge management and Industry 4.0 model that consolidates innovation processes in Colombian organizations. Methodology: A systematic mapping of information was developed, focused on the academic databases of the publications that link the concepts of Knowledge management, Industry 4.0 and Open innovation in the period 2016-2019. Conclusions: Innovation is a key factor for organizations, in particular to achieve competitiveness. For this, it is necessary to have inter-institutional and intra-institutional knowledge management models, characterized by the decentralized exchange of information in the context of Industry 4.0. Therefore, it is necessary that the governance of an organization understand and facilitate the processes of opening and exchanging knowledge and information. Originality: This model allows for the convergence of different models of administration and organization management, which must be co-managers of resource management and human talent. Limitations: The model is developed from the literature review and from the experiences presented in these investigations, implying that a second stage is necessary for validation with experts.