No abstract

During an outcomes study of spasticity treatment at a developmental center for 62 residents with profound intellectual disabilities, either botulinum toxin A (BTX-A), intrathecal baclofen (ITB), or both were recommended with physical and occupational therapy. Conservators consented to BTX-A more than ITB (p = .021). Court-appointed conservators were more likely to provide consent for treatment than family members (p = .026). Nonparents consented more than parents (p = .009). Finally, Caucasian conservators were more likely to consent to treatment than African American conservators (p = .036), but ethnicity of the resident did not influence consent. Gender of resident or conservator did not influence rate of consent. This report highlights disparities in surrogate consent giving for individuals with intellectual disabilities and indicates a need for more research to ensure that this vulnerable population has access to appropriate treatments.

No abstract

Discuss the clinical features, differential diagnosis, and management of HIV-associated neurocognitive disorders. • CD8+ T cell encephalitis has been described as a severe form of HIV-associated neurocognitive disorder (HAND). • The central nervous system (CNS) penetration effectiveness score has been correlated with cerebrospinal fluid (CSF) viral escape....