Major complications after TACE remain rare but deadly, the main complications can be vascular: within the access artery or the hepatic artery, or non-vascular: post-embolization syndrome (PES), biliary tract injuries, non-target regional or distant (cerebral or pulmonary) embolization, intra-or extra hepatic infection, TACE induced hepatic failure, hepatic rupture and many others. We report 3 complications in 2 patients: hepatic abscess, portal thrombosis and hepatic failure. The 2 patients unfortunately died after severe hepatic failure. Both of the two patients developed portal thrombosis after chemoembolization. This is the first case report of portal thrombosis developed after TACE with an extended hepatic necrosis in the second case. This article reviews different aspects of liver abscess complicating TACE for HCC.