No abstract

Liquid chromatography and electrochemistry have been combined ( L C E C ) t o form a new analytical approach with unique c a p a b i l i t i e s . While LCEC i s now well established f o r oxidizable substances, i t s use f o r determination of reducible compounds i s just beginning t o develop. The electrochemistry of e a s i l y reducible functional groups (electrophores) i s b r i e f l y discussed. Factors which influence the performance of reductive mode detection a r e reviewed, including mobile phase composition, electrode material , voltage waveform, and dissolved oxygen. Recent applications o f reductive mode LCEC a r e presented. I . INTRODUCTION Progress in theoretical electrochemistry has been rapid over the past t h i r t y years; however, a completely s a t i s f a c t o physical and chemical interpretation which accounts f o r differences in electrode r e a c t i v i t i e s (overpotentials) i s s t not we1 1 understood. DC pol arography and re1 ated vol tammetr techniques have been used f o r the determination of 1 i t e r a l l y thousands of environmentally and biologically important Y 11 C compounds. s e l e c t i v e , provided t h a t the sample i s not very complicated. These techniques a r e very s e n s i t i v e and reasonably 321 Copyright 0 I98 I by Marcel Drkker, Inc. Downloaded by [Monash University Library] at 16:38 04 June 2016 322 BRATIN AND KISSINGER U n f o r t u n a t e l y , samples o f b i o l o g i c a l , environmental , and c l i n i c a l i n t e r e s t are u s u a l l y complex and o f t e n r e q u i r e i s o l a t i o n steps p r i o r t o electrochemical determinations. As a r e s u l t , c l a s s i c a l v o l t a m n e t r i c techniques have f o r the most D a r t remained an academic c u r i o s i t y . The combination o f an i s o l a t i o n ( s e p a r a t i o n ) technique w i t h electrochemical d e t e c t i o n i n an "on 1 i n e " arrangement has given e l e c t r o c h e m i s t r y a new f o l l o w i n g as a p r a c t i c a l a n a l y t i c a l t o o l .

No abstract

No abstract

No abstract