A concise route to the title compound was achieved via annulation of 4,4-dimethylcyclohexenone with 3-cyanophthalide, followed by oxidation with DDQ.

Efficient Synthesis of 4,4-Dimethyl-1,9,10(1H)-anthracenetrione. -A concise route for the preparation of title compound (V), a compound with potent lytic activity in vitro against T. cruzi, via annulation of 4,4-dimethylcyclohexenone with 3-cyanophthalide (III), followed by oxidation with DDQ is described. -(CRAWLEY, M. L.; HEIN, K. J.; MARKGRAF*, J. H.; J. Chem. Res., Synop. 2003, 8, 470-471; Dep. Chem., Williams Coll., Williamstown, MA 01267, USA; Eng.) -M. Schroeter 11-099