In this research, an innovative physicochemical strategy is presented to address the problem of nejayote, from two perspectives: the first focusing on sanitation and reuse of nejayote using waste from shrimp shells, thereby adding value to the recovered solids of nejayote. Zeta potential measurements are a proactive electrochemical tool to define the strategy to allow integral use of nejayote in the industry nixtamalization. The treated water can be discharged from the municipal sewer system using a process of coagulation-flocculation, with an optimal dose of 1250 mg/L chitosan at pH 5, achieving removal of up to 80% of total suspended solids and turbidity. Moreover, zeta potential measurements show that the anionic biopolyelectrolyte obtained from nejayote has potential to be applied in the area of water treatment as a green chelating agent.