PURPOSE:To investigate whether there is any effect resulting from preconditioning with nutraceutical supplementation containing arginine and oil mixes with high ω9:ω6 ratio and low ω6:ω3 ratio containing EPA and DHA, ALA fatty acids on inflammatory mediators, antioxidant and lipid profile modulation in surgical trauma. METHODS:Twenty-six men scheduled for radical prostatectomy were randomized into three groups and treated as follows: Group 1 (skim milk, 0% fat), Group 2 (supplement with ω6:ω3 ratio of 8:1 and arginine) and Group 3 (supplement with high ω9:ω6 ratio of 3.2:1 and low ω6:ω3 ratio of 1.4:1 and arginine). Patients received skin milk or supplements twice a day (200 ml) during five days prior to surgery. Peripheral venous blood samples were collected at three different timepoints: five days before surgery (PRE), before anesthesia induction (IND) and on the 2 nd postoperative day (POS). Parameters analyzed included inflammatory cytokines (IL-1β, IL-6, IL-8 and TNF-α), antioxidants (catalase), lipid profile and heat shock protein (HSP-27). RESULTS:There were no significant differences between groups on inflammatory mediators and antioxidant parameters. However, lipid profile values (Cholesterol, LDL, Triglycerides, VLDL), were significantly different. CONCLUSION:Preconditioning with arginine and oil mixes containing high ω9:ω6 ratio and low ω6:ω3 ratio, has no effects on inflammatory mediators and oxidative stress in patients undergoing radical prostatectomy. Reduction of cholesterol, triglycerides, LDL and VLDL profiles may be related to the trauma effect.

A supplement widely used in resistance training is creatine, which is composed of three amino acids (arginine, glycine, and methionine). It is found primarily in skeletal muscle (95%) and plays an important role in the rapid supply of energy during muscle contraction via the ATP-CP system. Because of this, in this study, an integrative literature review was carried out, to understand the positive effects and renal changes of creatine in physical exercises. The research was carried out between September 2021 and May 2022, with searches in PubMed and Scielo databases. The following descriptors from the DeCS (descriptors in health science created by BIREME) and MESH (medical subject headings) were used: "creatine supplementation", "dose-dependent creatine", "creatine", "Creatine Supplementation and Exercise Training". Most studies have shown that creatine supplementation (CR) is important for resistance training and muscle performance and is an effective resource in increasing energy, as creatine is involved in one of the metabolic energy delivery systems, in which Adenosine bisphosphonates (ADP) are enzymatically linked to phosphocreatine (CP) to regenerate adenosine triphosphate (ATP), the main energy currency. After creatine supplementation, there is more CR in the muscles, which favors an increase in energy supply through ATP resynthesis.

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Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição 4.0 Internacional (CC BY 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.

No abstract