a split-thickness skin graft, with no recurrence at 12month follow-up.Hair repigmentation as a sign of malignancy has been scarcely reported in the literature. [1][2][3][4][5] Although rare, it has been proved to be the leading sign to the diagnosis of lentigo maligna, invasive melanoma lentigo maligna type and desmoplastic melanoma and therefore must be kept in mind as an indirect sign of malignancy. 2,3 It has been exclusively described in elderly patients, explained by the physiological white hair discoloration in this population and that was also present in our patient despite his younger age. Previous reports show a clear female predominance with only two male cases reported including the present case, 1 probably due to the higher prevalence of androgenetic alopecia in male population. Histopathological examination of previous reports has described the presence of an increased number of dendritic melanocytes and melanin pigment in the hair bulbs of affected areas. 1,2,4 Several theories have been postulated to explain this phenomenon such as induced melanin production in the hair follicle by melanoma cells through growth factors or pigment transfer from the tumoral cells to surrounding keratinocytes, although the exact mechanism remains unclear. 1,3 This case exemplifies the relevance of considering hair repigmentation as a red flag not only for dermatologists but also other physicians in order to avoid delayed diagnosis.
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