Clinical chorioamnionitis is characterized by changes in the expression of the alarmin HMGB1 and one of its receptors, sRAGE.

al.] Pharmacology and anti-addiction effects of the novel κ opioid receptor agonist Mesyl Sal B, a potent and long-acting analogue of salvinorin A. British Journal of Pharmacology. 2015;172:515-531. 20. Smith E. S., Lewin G. R. Nociceptors: a phylogenetic view. J. Comp. Physiol. A. Neuroethol. Sens. Neural. Behav. Physiol. 2009;195(12) A comprehensive examination of 114 patients with stage I and II hypertension was carried out. The aim of the study was to develop a modern, pathogenetically substantiated, comprehensive non-medicamentous method of curative correction of early cerebral manifestations of hypertension. The main correction of the initial manifestations of hypertension was a special technique of curative gymnastics and respiratory gymnastics with elements of group psychotherapy. Group 1 (n=80) -patients who received complex non-drug treatment; Group 2 (n=34) -patients who received drug-induced antihypertensive therapy on the basis of monotherapy or low-dose combination therapy. Patients of the 1 st group reported a significant (p<0.01) improvement after the end of treatment. Intergroup differences obtained before and after treatment, in patients of the 1 st and 2 nd groups it had a significant (p<0.01) nature. The study of cerebral hemodynamics significantly (p<0.01) indicated an increase in the majority of patients of the 1st group of blood flow along the vertebral arteries, the posterior cerebral arteries. In the state of vasomotor reactivity and autoregulation of cerebral blood flow, there was significant (p<0.01) positive dynamics only in patients of the 1st group. Thus, the analysis of the results of our algorithm for treating patients with initial manifestations of hypertension, conducted with the use of non-drug methods, demonstrates the validity of the proposed pathogenetic approach to ongoing therapy. Keywords: arterial hypertension, therapy, combined therapy, nonmedical methodsБыло проведено комплексное обследование 114 пациентов с АГ I и II стадии. Цель исследования -раз-работать современный патогенетически обоснованный комплексный немедикаментозный метод лечебной коррекции ранних церебральных проявлений артериальной гипертензии (АГ). Основой коррекции начальных проявлений АГ являлась специальная методика лечебной гимнастики и дыхательной гимнастики с элемен-тами групповой психотерапии. 1-я группа (n=80) -пациенты, получавшие комплексное немедикаментозное лечение; 2-я группа (n=34) -пациенты, получавшие медикаментозную гипотензивную терапию на основе монотерапии или низкодозированной комбинированной терапии. Пациенты 1-й группы отмечали достовер-ное (p<0,01) улучшение после окончания лечения. Исследование церебральной гемодинамики достоверно (p<0,01) свидетельствовало об улучшении мозгового кровотока. В состоянии вазомоторной реактивности и ауторегуляции мозгового кровотока также отмечалась достоверная (p<0,01) положительная динамика только

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Неврология original research Neurology 318 In Russia more than 650000 people suffer a stroke each year, and approximately two-thirds of these individuals survive and require rehabilitation. The goals of rehabilitation are to help survivors become as independent as possible and to attain the best possible quality of life. Even though rehabilitation does not «cure» the effects of stroke in that it does not reverse brain damage, rehabilitation can substantially help people achieve the best possible long-term outcome [1, 6].The ischemic stroke is an accident, which, at a favorable outcome, leads to cardinal changes in human life and his relatives [12]. There is no patient without these changes in a way of life, mood and behavior. At the same time traditionally in a clinical picture of a stroke the main influence is given to the focal neurologic deficiency bound to a physical disability, first of all to disturbance of motor function. Meanwhile the psychoemotional disorders, speech problems and dysfunctionof autonomic nervous system arising at appreciable number of the poststroke patients, render on household, social and professional adaptation nearly larger effect, than motor deficiency and become an important problem [8, 11].Changes of autonomic regulation in case of acute brain ischemia are including both direct damage of the suprasegmental centers, and the neurometabolic shifts caused by stress factors. The deviations, arising in the regulating parts of the autonomic nervous system precede hemodynamic, metabolic, respiratory disturbances and, thus, can be the most valuable prognostic symptoms of the patient after the stroke [5]. Investigation of 106 patients in the early recovery period of an ischemic stroke is conducted. Autonomic nervous system dysfunction, speech problems and the psychoemotional disturbances are revealed. Strong correlation of aphasia and depression was demonstrated. Efficiency of an antioxidant treatment in correction of the revealed problems at the patients with an ischemic stroke is shown. Keywords: ischemic stroke, autonomic dysfunction, aphasia, dysarthriaПроведено исследование 106 пациентов в раннем восстановительном периоде ишемического инсульта. Выявлены дисфункция вегетативной нервной системы, речевые проблемы и психоэмоциональные наруше-ния. Была продемонстрирована сильная корреляция афазии и депрессии. Показана эффективность антиок-сидантного лечения при коррекции выявленных проблем у пациентов с ишемическим инсультом Ключевые слова: ишемический инсульт, вегетативная дисфункция, афазия, дизартрия