CONTEXT: The approximate incidence of periprosthetic supracondylar femur fractures after total knee arthroplasty ranges from 0.3 to 2.5 percent. Various methods of treatment of these fractures have been suggested in the past, such as conservative management, open reduction and plate fixation and intramedullary nailing. However, there were complications like pain, stiffness, infection and delayed union. Minimally invasive plate osteosynthesis (MIPO) is a relatively newer technique in the treatment of distal femoral fractures, as it preserves the periosteal blood supply and bone perfusion as well as minimizes soft tissue dissection. AIM: To evaluate the effectiveness of MIPO technique in the treatment of periprosthetic distal femoral fracture. SETTINGS AND DESIGN: In this study, we present a case report of a 54 year old female patient who sustained type 2 (Rorabeck et al. classification) periprosthetic distal femoral fractures after TKA. Her fracture fixation was done with distal femoral locking plates using minimally invasive technique. METHODS AND MATERIAL: We evaluated the clinical (using Oxford knee scoring system) and radiological outcomes of the patient till six months post-operatively. Radiologically, the fracture showed complete union and she regained her full range of knee motion by the end of three months. CONCLUSION: We conclude that MIPO can be considered as an effective surgical treatment option in the management of periprosthetic distal femoral fractures after TKA.