Schiff bases are aldehyde or ketonic-like compounds in which an imine group replaces the carbonyl group and has been synthesized by condensing primary amines with an active carbonyl compound. Synthesis of two new Schiff base (NE)-N, 2-bis (2-methoxybenzylidene) hydrazine-carbothioamide and (2E)-N, 2-bis (3methoxybenzylidene) hydrazine- carbothioamide by Thiosemicarbazide with 2 methoxy benzaldehyde and 3 methoxy benzaldehyde via a condensation reaction. Metal complexes of synthesized Schiff bases have been synthesized via these Schiff base ligands with different metal ions. (Cu2+, Ni2+, Fe2+, Co2+etc) These compounds have been synthesized by the reflux method and characterized by a Spectroscopic Technique i.e., FT-IR, UV, 1H-NMR, and Mass (HRMS). The structure of the ligands was clarified by spectral studies which indicate the presence of two or four coordinating groups in ligands. Antimicrobial strain Bacillus subtilis fungi Aspergillus Niger is used for testing the antimicrobial activity. Results also indicate that the metal complexes are expected to be more biologically active as compared to the precursor. The structure of the ligands was clarified by the above spectral studies, which indicates the presence of two or four coordinating groups in ligands.

<p>In this study, we have outlined a conventional and user-friendly procedure for the production of <em>(E)-1-(((5-ethyl-1,3,4-thiadiazol-2-yl)imino)methyl)naphthalen-2-ol </em><em>(HL-1)</em> and <em>(E)-1-((thiazol-2-ylimino)methyl)-naphthalen-2-ol</em> (HL-2) by the reaction of heterocyclic amine, aldehyde in the presence of ethanol as a solvent and acid as the catalyst. The synthesis of new HL-1 and HL-2 may be accomplished with ease using this approach, which is also very efficient. In the presence of dipositive Co, Ni, and Cu metal complexation, HL-1 and HL-2 were carried out in the presence of metal: ligand (1:2). HL-1, HL-2, and metal complexes are characterized with the assistance of UV/visible, FT-IR, Mass, and ¹H NMR spectroscopy respectively. Furthermore, the ligands mentioned above (HL-1 and HL-2) and their metal complexes were tested for the antimicrobial study and showed an excellent inhibitory zone. These investigations indicated that HL1<strong>-</strong>Co (II), HL-1Cu (II), complexes and ligands HL-2Co (II), and HL-1Ni(II) had positive effects on <em>Escherichia coli</em> causing severe stomach cramps (Gram-negative- MTCC 1610) and positive impact on <em>Staphylococcus aureus</em> (Gram-positive MTCC<strong>-</strong>96) due to skin infections.</p>