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In the present study the ethanolic extract of Aquilaria malaccensis (Agar wood) leaves before inoculation (BF) and after inoculation (AF)) was evaluated for its anticancer potentials. The leaf extracts (BF and AF) was subjected to in-vitro cytotoxicity studies on EAC cells, normal spleen cells and DLA cells. The leaf extracts showed dose dependent cytotoxicity with increase in dose. The IC50 value for BF and the AF leaf extract was 79.09μg/ml and 79.20μg/ml respectively. The effect on primary spleen cells was observed to be more than 100μg/ml. The study concluded that the extract of the said plant leaves has significant potential anticancer activity. All these results clearly indicate that the crude extract has a remarkable capacity to inhibit the growth of Ascites tumor induced by EAC cell line in animals.

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This review aims to explore the essence of Annona muricata Linn. A. muricata frequently called soursop guanabana and graviola belongs to the family Annonaceae and has a long history of traditional uses. This is an evergreen plant found in tropical and subtropical regions of the world mostly seen in Africa South America and South East Asia. The miracle nature of the A. muricata plant is a boon to mankind and has been widely used in folk medicine. Various preparations of A. muricata available in the market include candies syrups beverages ice creams and shakes. Several investigations conclusively report that the plant possesses more than 212 chemical constituents such as acetogenins alkaloids and phenols. The plant has a wide range of therapeutic effects including antibacterial antiviral antifungal antitumor anthelminthic analgesic antiarthritic hypotensive anti-inflammatory immune enhancing effects and anti-diabetic activity. The extract of A. muricata is found to be effective and safe although some reported toxicities cannot be denied. This review attempts to unite most of the available information regarding phytochemistry traditional uses biological activities and toxicity related to A. muricata.

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