A series of seven earthquakes with magnitude М>5.0 recorded during the year from September 2020 to September 2021 in the southern part of the Baikal region was studied. Based on ground data “background” time intervals were identified when there was a seismic lull in this area. Based on satellite data ATMS/SNPP seismo-gravitational fluctuations in temperature and pressure at the isobaric level of 300 hPa were detected. It was revealed that during the preparation of the Baikal earthquakes harmonics with a period of 92-96 hours appear in the spectrum of temperature fluctuations. Such harmonics are absent in the background temperature series.