Introduction: Cervical cancer is one of the most common cancers and takes the second place among women's cancers in terms of incidence and the first place in terms of breast cancer mortality. Its incidence and mortality are significantly increased in patients living with HIV / AIDS. The purpose of this work is to describe the cytopathological and molecular aspects of cervical dysplasia in HIV-positive women in our environment and to look for some associated factors, in particular the degree of immunosuppression and the clinical stage. Methodology: This was a cross-sectional, descriptive, and analytical study of cervical-uterine smears (n = 111) and human papillomavirus genotyping (n = 73) in HIV-infected patients received from January 2018 to December 2018 at Panzi GRH (South Kivu, DR Congo). The data analysis was done using SPSS statistics 20 software. Results: The average age of the patients was 42.25 ± 10.42 years. The cervical-uterine smear (CUS) was normal in 82.9% of cases and cytological abnormalities were found in 13.5% of cases. The majority of patients were in WHO stages I (45.9%) and II (45.0%) of HIV infection and had a CD4 count greater than 500 cells / mm3 in 47.9% of patients. Among the 73 patients who had been tested for HPV infection, 35 (47.9%) were positive. The most common carcinogenic genotype among HPV positive patients was 18-45 (17.1%). There was not a significant difference in carcinogenic genotypes and intraepithelial lesions as a function of WHO clinical stages (p = 0.3819 and p = 0.7945). Conclusion: The coexistence between HIV and HPV infections seems to be strongly associated with the occurrence of cervical cytological abnormalities in our sample study. Hence the need, on the one hand, for a national policy for early detection of cervical cancer in all patients living with HIV / AIDS, and on the other hand, for deepened studies at the international level for the tuning of a plurigenic vaccine containing all oncogenic genotypes, those one that are geographically widespread (genotypes 16 and 18) are not more common to HIV-positive patients in our study environment

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Introduction: Human papillomavirus (HPV) infection remains the most common cause of cervical intraepithelial neoplasia. The objective of this study is to evaluate the sensitivity and predictive value of the HPV test associated with the cervico-uterine smear in the screening of cervical intraepithelial neoplasia in our environment. Methodology: This is a descriptive cross-sectional study of 625 women who consulted in the department of gynecology for cervical cancer screening, of whom 300 received an HPV test; during the period from January the 1st to December 31st, 2018 at Panzi general reference hospital (South-Kivu, DRC). Data analysis was done using Epi Info version 7 software. Results: For all respondents (n = 625), the cervico-uterine smear was normal in 82.88%, inflammatory in 2.4% of cases and with cellular atypia in 14.72%. The HPV test was positive in 87 respondents against 213 negatives cases, i.e. a prevalence of HPV of 29% [95% CI: 23.9% -34.5%]. Among women with precancerous lesions, 27.6% had HPV infection; among those with normal smears, 29.3% of them had HPV infection; however, this difference was not statistically significant. Patients with dysplastic lesions, 31.3% had genotypes with very high carcinogenic potential; and for those with a normal Pap smear, 45.1% had genotypes with very high carcinogenic potential; however, this difference was also not statistically significant. Conclusion: The human papillomavirus test remains a very important indication