Nowadays, the implants are used medically in various parts of human body, for example dental implants, cartilage replacements, joints, ties, tendons etc. Before the actual implantation, it is necessary to verify the safety and suitability of the implant use in that certain body part. That is done on the basis of the biocompatibility of the material used to produce the "artificial" replacement. The biocompatibility is basically the tolerance of different substances in biological environment. It is evaluated according to interactions between the given material and the organism (tissue), or between the environment, it is placed into. If the implant is incompatible with the organism, the organism will not adopt the implant, thus the implantation itself is not suitable. There are special materials called biomaterialsthese are able to work in conjunction with living organism and having minimum of adverse effects. The initial evaluations are ongoing on the cell-and protein levels.

The thesis explains orthotic influence of myelomeningocele-spine bifida, which depends on age, damage level and patient's disease. The main goal of this thesis is to evaluate the influence and effect of orthoses on patient's image of walking. HKAFO orthosis (an orthosis influencing the hip, knee and ankle joints and the foot) is designated for patients in need of stabilization or compensation, when the lower limb is paralyzed, but the strength of hip and partially of knee extensor is kept, or when the lower limb is completely paralyzed. Correct type of RGO allows the patient to walk faster and with less energy consumption. The goal of the orthosis application is verticalization in the most possible physiological standing and locomotion.