Background: A disintegrin and metalloprotease 17 (ADAM17) releases many proinflammatory mediators. Results: The conserved ADAM seventeen dynamic interaction sequence (CANDIS) mediates effective substrate binding and is controlled by the disulfide-regulated conformation of the preceding membrane-proximal domain (MPD). Conclusion: CANDIS, together with the MPD, represents a novel key regulatory element. Significance: We investigate the molecular details of a novel kind of regulation.
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