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Background: JAK inhibitors are cytokine modulators that are effective in the treatment of numerous autoimmune diseases. However, given their immunosuppressive effects, they may, at least potentially, increase the risk of severe herpes infection in individuals with atopic dermatitis.Objective: To assess the utility of preventative antiviral treatment when initiating JAK inhibitors for atopic dermatitis in order to decrease risk of eczema herpeticum.Results: JAK inhibitors, specifically tofacitinib and baricitinib, used for the treatment of atopic dermatitis confer an increased risk of herpes simplex virus infection. Acyclovir and valacyclovir are effective, safe, and affordable for herpes simplex virus prophylaxis. 26.Bieber T, Thyssen JP, Reich K, et al. Pooled safety analysis of baricitinib in adult patients with atopic dermatitis from 8 randomized clinical trials.

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