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s i t y of Minnesota, Minneapolis. (spon. by Robert A. Ulstrom.) We have observed t h e a s s o c i a t i o n of profound hypoglycemia and a n t e r i o r h y p o p i t u i t a r i s m i n f o u r newborns. A l l p r e s e n t e d w i t h hypoglycemia during t h e f i r s t 30 hours of l i f e , which reached l e v e l s l e s s than 10 mg.%. Rates of 20-30 mg./kg./min. of 20% d e x t r o s e were required t o m a i n t a i n g l u c o s e l e v e l s above 30 mg.%. A l l i n f a n t s were products of complicated pregnancies and d e l i v e r i e s and had APGAR s c o r e s of f i v e o r l e s s a t one and f i v e minutes Measurements of a n t e r i o r p i t u i t a r y f u n c t i o n i n c l u d i n g serum TSH, T4, ACTH, c o r t i s o l and growth hormone, i n a d d i t i o n t o metapyrone and cosyntropin s t i m u l a t i o n , revealed a n t e r i o r panhypop i t u i t a r i s m i n t h r e e i n f a n t s and i s o l a t e d ACTH d e f i c i e n c y i n t h e o t h e r . P o s t e r i o r p i t u i t a r y f u n c t i o n was normal i n a l l cases. Unresponsiveness of TSH t o i n t r a v e n o u s t h y r o t r o p i n r e l e a s i n g hormone (TRH) and normal serum p r o l a c t i n l e v e l s f u r t h e r support a n t e r i o r p i t u i t a r y d y s f u n c t i o n i n c o n t r a s t t o a hypothalamic e t i o l o g y . Autopsy on one i n f a n t revealed no a n t e r i o r p i t u i t a r y t i s s u e . The t h r e e s u r v i v i n g p a t i e n t s a r e a l l doing w e l l on a p p r o p r i a t e hormone replacement. Micropenis was p r e s e n t i n t h e one male and a l l i n f a n t s showed a widening of t h e midfacies. T h i s unappreciated cause of e a r l y n e o n a t a l hypoglycemia may b e r e l a t e d t o b i r t h hypoxia o r anatomic malformation of t h e ante r i o r p i t u i t a r y and i t s rudiments.These may b e more s u s c e p t i b l t o e v e n t s a t b i r t h than p r e v i o u s l y a p p r e c i a t e d and consequently I t h i s system should b e more a g r e s s i v e l y evaluated i n newborns.ANTIBODIES TO LUTEINIZING HORMONE I N A PATIENT TREAT-ED WITH GROWTH HORMONE. S. B u r s t e i n , F.A. Conte. S .L. Kaplan, and M.M. Grumbach. Dept. P e d i a t r i c s , Univ. of an Francisco, San Francisco, Ca. Many c l i n i c a l grade p r e p a r a t i o n s of hGH (human growth hormone) a r e contaminated w i t h hLH and hFSH. However, no evidence of a c l i n i c a l e f f e c t of such contamination has been d e s c r i b e d . We rep o r t t h e development of a n t i b o d i e s t o hLH i n a p a t i e n t t r e a t e d with hGH f o r i s o l a t e d G H d e f i c i e n c y .J.C. was f i r s t i n v e s t i g a t e d f o r s h o r t s t a t u r e a t 7-11/12 y e a r s and G H therapy was begun a t 8-9/12 y e a r s f o r a d i a g n o s i s of i s ol a t e d GH d e f i c i e n c y . On LRF ( l u t e i n i z i n g hormone r e l e a s i n g f a c t o r t e s t i n g , t h e LH r o s e from 0 . 8 t o 1 . 2 ng/ml (LER 960); FSH respons s l s o was normal....