What is already known on this topic?The incidence of cancer is rising among women; 42% of cancers among men and women are associated with modifiable risk factors.What is added by this report?We used 18 years of population-based data to determine trends in the incidence of cancers that are associated with 5 modifiable risk factors. The incidence of obesity-associated cancer is rising, particularly among women aged 20 to 49 years (vs ≥50 y) and Hispanic women.What are the implications for public health practice?Our findings help advance the understanding of cancer prevention. Studies that examine the effect of obesity on cancers diagnosed among young and Hispanic women are warranted.