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sections. Quantitative analysis of VEGF was performed by ELISA. Expression profiles were correlated and analyzed for diagnostic accuracy and reproducibility. RESULTS: Specimens were collected from a total of 24 subjects (12 PAS, 6 previa, 6 control). VEGF urine quantities were assessed by ELISA. Average urine VEGF quantities were 8.7, 10.2, and 24.1 pg/ mL for control, previa and PAS subjects respectively (p¼0.01). In addition the PAS cohort was subdivided by traditional pathology (accreta, increta, percreta). VEGF expression was 7.9, 18.3 and 29.6 pg/mL for accreta, increta and percreta, respectively (p<0.016). CONCLUSION: Urine expression of VEGF in PAS subjects allows for minimally-invasive discrimination of PAS from control or patients with placenta previa. In addition, VEGF expression correlates with degree of final pathology. In summary, VEGF may be a potential biomarker for identification of PAS patients and predictive of PAS degree of pathology.

temic vascular resistance (SVR) were obtained using USCOM-1A. USCOM-1A employs continuous-wave Doppler, with a non-imaging probe placed in the suprasternal notch, to obtain velocity-time integrals of transaortic blood flow at the left ventricular outflow tract. Intraobserver repeatability was assessed by each patient having 2 USCOM measurements obtained by first investigator. Interobserver reproducibility was assessed with another set of USCOM measurement performed by a second investigator. The measure of reliability of the parameters was the intraclass correlation coefficient (ICC). Results: Study included 107 women, the mean age was 33.46 years, BMI was 22.78 kg/m 2. Mean value of MAP was 90.99 Torr (min. 70, max. 110). Mean value of CO was 6.99 l/min with standard deviation (SD) 1.42 (min. 3.9, max. 11.0). Mean value for SV was 89.11 ml with SD 15.61 (min. 54, max. 151). Mean value of SVR was 1088.76 dynes x s/cm 5 with SD 231.69 (min. 629, max. 1923). The intraobserver ICC for hemodynamic parameters ranged from 0.94 to 0.95 and from 0.87 to 0.91 for the first and second investigator respectively. First investigator had the highest correlation in measurements of CO (ICC-0.95), second investigator in measurements of SVR (ICC-0.91). The interobserver ICC for hemodynamic parameters ranged from 0.83 to 0.89. The best correlation was found for measurements of SVR (ICC-0.89). Conclusions: In our cohort of patients measurement with USCOM had good intraobserver repeatability and good interobserver reproducibility, therefore we can continue with our prospective cohort study on maternal hemodynamics in pregnancy.

Rogg K, Robinson WR. Compliance with highly active antiretroviral therapy (HAART) does not prevent human papilloma virus (HPV)-related cancers in women infected with human immunodeficiency virus.

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