[reaction: see text] The application of microwave heating to a polymer-assisted solution-phase (PASP) synthesis technique has been utilized to develop a rapid and efficient protocol for the solution-phase synthesis of amides from either amine or carboxylic acid cores.

Pyrazole derivatives R 0180 Scaffold Oriented Synthesis. Part 1. Design, Preparation, and Biological Evaluation of Thienopyrazoles as Kinase Inhibitors. -Libraries based on the thienopyrazole scaffold [cf. (VIII), (XIII), (XIV)] are synthesized and evaluated in a panel of kinase assays. Several members show kinase inhibitory activity at submicromolar concentrations against KDR. -(AKRITOPOULOU-ZANZE*, I.; DARCZAK, D.; SARRIS, K.; PHELAN, K. M.; HUTH, J. R.; SONG, D.; JOHNSON, E. F.; JIA, Y.; DJURIC, S. W.; Bioorg. Med. Chem. Lett. 16 (2006) 1, 96-99; Abbott Lab., Abbott Park, IL 60064, USA; Eng.) -D. Singer 13-132

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