Organic Chemistry I presents challenges to many students pursuing diverse fields of study, oftentimes curtailing further progress in those fields. The ability to identify students at risk of unsuccessful course...
E‐substituierte Styrole wurden durch TiIV‐vermittelte oxidative Kupplung aus terminalen Olefinen und Grignard‐Reagentien synthetisiert (siehe Schema). Das Substratspektrum umfasst Homoallylalkohole mit verschiedensten funktionellen Gruppen sowie substituierte Aryl‐Grignard‐Reagentien. Die Reaktion verläuft vermutlich über eine Aryltitanierung mit anschließender β‐Hydrid‐Eliminierung; das Aren wird dann aus einem TiIVH(Aryl)‐Intermediat eliminiert.
The title compound, C16H14FNO3, was synthesized via solid phase methods; it exhibits monoclinic (P21) symmetry at room temperature. The two independent molecules that comprise the asymmetric unit display distinct torsion angles of 173.2 (2) and 72.6 (2)° along the central sp3 C—N bond. In the crystal, hydrogen bonding through N—H...O contacts couples the asymmetric unit molecules into pairs that align in layers extending parallel to (100) via additional O—H...O interactions. The phenyl ring of one independent molecule was found to be disordered over two sets of sites in a 0.55 (3):0.45 (3) ratio.
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