Lefamulin, a semisynthetic pleuromutilin antibiotic approved in the United States, Canada, and Europe for intravenous and oral treatment of community-acquired bacterial pneumonia, is highly active
in vitro
against bacterial pathogens that cause sexually transmitted infections (STIs), including multidrug-resistant strains of
Neisseria gonorrhoeae
,
Chlamydia trachomatis
, and
Mycoplasma genitalium
. This nonclinical study used quantitative whole-body autoradiography (QWBA) and qualitative tape-transfer microautoradiography (MARG) to investigate lefamulin distribution into urogenital tract tissues down to a cellular level in male and female rats.
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