The use of nurses as clinical advisors in an interprofessional COVID-19 crisis command center proved successful. By engaging nurses as clinical advisors in the command center structure, one organization was able to facilitate optimal decisions around nursing leadership and advocacy, capacity and staffing, the development and implementation of innovative novel care models, clinical training and upskilling, and maintaining the safest possible environment for the patients and team members. Including a nurse-led clinical advisor role within future command center structures is an important strategy to reshaping how organizations effectively respond in times of crisis.