Rationale and Objectives: To investigate if anisotropy at 2D Shear Wave Elastography (SWE) suggests malignancy and whether it correlates with prognostic and predictive factors in breast cancer. Materials and Methods: Study-group A of 244 solid breast lesions was imaged with SWE between April 2013 and May 2014. Each lesion was imaged in radial and anti-radial planes and the maximum elasticity Emax, mean elasticity Emean and standard deviation SD were recorded and correlated with benign/malignant status and if malignant, to conventional predictive and prognostic factors. The results were compared to a study-group B of 968 solid breast lesions, which were imaged in sagittal and axial plane between 2010 and 2013.
The biomechanical effect of CXL using the femtolaser pocket technique is about 50% less pronounced than that after standard CXL. Future studies will show whether the efficacy of the technique can still be improved and whether the clinical effect is sufficient for stabilizing ectatic corneas.
Mr. Klenke and Ms. Skerl were paid employees of Wavelight GmbH when the study was performed. Dr. Seiler is a scientific consultant to Wavelight GmbH. No other author has a financial or proprietary interest in any material or method mentioned.
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