COVID-19 and multisystem inflammatory syndrome in children (MIS-C) can mimic and cause acute abdominal diseases such as intestinal obstruction, terminal ileitis, colitis, internal necrotizing mesenteric lymphadenitis, acute appendicitis, and sometimes bowel perforation. We report a case of a 6-year-old female with MIS-C and acute purulent pelviperitonitis, who was successfully treated by laparoscopy and an antibiotic without intravenous immunoglobulin and aspirin therapy. We believe that the case description should help to find a worthy place for early laparoscopic and other minimally invasive procedures for the management of similar MIS-C cases.