Katsuhiko Iseki scite author profile

This paper describes the discovery of a novel free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone, 1), as a potent antioxidant agent against lipid peroxidation. The structure-activity relationship of edaravone indicated that lipophilic substituents were essential to show its lipid peroxidation-inhibitory activity. In vivo studies revealed that edaravone showed brain-protective activity in a transient ischemia model.

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Catalytic asymmetric synthesis of chiral fluoroorganic compounds

Iseki¹

1998

Tetrahedron

123

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Katsuhiko Iseki

Asymmetric trifluoromethylation of aldehydes and ketones with trifluoromethyltrimethylsilane catalyzed by chiral quaternary ammonium fluorides

Asymmetric allylation with chiral formamide catalysts

Asymmetric allylation of aromatic aldehydes catalyzed by chiral phosphoramides prepared from (S)-proline

Structure–activity relationship of 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone)

Catalytic asymmetric synthesis of chiral fluoroorganic compounds

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