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The authors carried out compressive and tensile loaed tests of cast-inplace concrete nodular piles and clarified that the resistance of the pile increased by the effect of the node. And we could simulate well the vertical behavior of them by non-linear 3D-FEM. And we adapted the simulation method to the settlement analysis for the pile foundation supporting high-rise building under dead load and seismic load. In these analytical studies, we clarified that the building load to the piles are influenced significantly by the rigidity of the foundation beams, basement walls and pile group effect.