Aim:The purpose of the present experimental study was to assess the antihyperglycemic activity of ethanolic extract of Linum usitatissimum seeds and Glycyrrhiza glabra roots with standard drugs metformin and glimepiride in streptozotocin-induced diabetic rats model. Materials and Methods: Total 42 Wistar albino rats were utilized in this study which separated into seven groups with six animals in each group. Negative controls for normal base line reading and was not induced with diabetes were administered 0.9% sodium chloride (NaCl). and positive control i.e. in which diabetes was induced with streptozotocin were administered 0.9% sodium chloride Original Research Article

Diabetes mellitus, a silent killer, is a disease which is characterized by altered metabolism of carbohydrate, protein and lipids, classically present as raised blood glucose levels. The prevalence of diabetes mellitus in increasing rapidly in both high and low-income countries. Diabetes mellitus is characterized by uncontrolled high blood glucose levels as an outcome of deficient pancreatic insulin release or poor insulin-coordinated utilization of glucose by glucose utilizing cells. Diabetes mellitus is related to a number of metabolic manifestations like atherosclerosis, with further consequences like cardiovascular disease and stroke that can lead to premature death. Numerous therapeutic agents that are available for the treatment of diabetes however these drugs have a number of restrictions, and the whole restoration from diabetes have not been accounted up till now. Herbs have been utilized from old time to cure the humankind because of their presumed lesser adverse effects, relatively high availability and relatively low cost; herbs are admired by general public. This review high lights the role of different herbs in the treatment of diabetes mellitus along with their predicted mechanism of action in relation to clinical investigations.