Spectral data of coumarin isoxazoline derivatives 11a-d. Spectral data of coumarin isoxazoline derivatives 12a-d.1 H NMR , 13 C NMR, Mass and Elemental analysis Spectra of compound 11a.1 H NMR , 13 C NMR, Mass and Elemental analysis Spectra of compound 12a.

A facile one-pot synthesis of 5-benzoyl-6-methylthio-1,2,3,4-tetrahydropyrimidines in good yields is reported.

Background: A new series of quinazoline linked chalcone conjugates were synthesized and evaluated for their in vitro cytotoxicity. Methods: The quinazoline-chalcone derivatives (13a-r) have been prepared by the Claisen-Schmidt condensation of various substituted benzaldehydes (12a-r) with substituted l-(4-(3,4dihydroquinazolin-4-ylamino)phenyl)ethanone (11a-b) in the presence of aqueous NaOH. Three potential compounds 13f, 13g and 13h exhibited cytotoxicity against leukemia (GI 50 value of 1.07, 0.26 and 0.24 µM), Non-small lung (GI 50 values of 2.05,1.32 and 0.23 µM), colon (GI 50 values of 0.54, 0.34 and 0.34 µM) and breast (GI 50 values of 2.17, 1.84 and 0.22 µM) cell line, respectively. Results and Conclusion: Based on these biological results, it is evident that compound 13h has the potential to be considered for further detailed studies either alone or in combination with existing therapies as potential anticancer agents.

.5-Nitro-1,2,3,4-tetrahydropyrimidine derivatives [1,2] are known to possess important biological properties. However, bis-5-nitro-1,2,3,4-tetrahydropyrimidines are unknown in the literature. In continuation with our on-going program on the synthesis of tetrahydropyrimidines [3,4], we herein report the synthesis of the title compounds. A mixture of ethylenediamine (30 mg, 0.5 mmol) and formaldehyde (60mg, 2 mmol, 40% solution) was stirred in methanol (2 mL) for 5 minutes and to this a solution of 1-nitro-2-anilino-2-methylthioethene 1 [5] (210 mg, 1mmol) in methanol was added and the resulting mixture was stirred at room temperature for 2 hours, when a yellow solid precipitated out. After the completion of the reaction (monitored by tlc), the reaction mixture was cooled in ice water and the solid filtered, washed with MeOH (2X2 mL) to give pure 2a (150 mg, 57%), which was recrystallized from methanol. The product 2b was obtained in 81% yield by the same procedure by replacing ethylenediamine by butylenediamine.Bis-(1-phenyl-5-nitro-6-methylthio-1,2,3,4-tetrahydropyrimidinyl)ethane (2a). Mp: 135-1360 C (methanol, uncorrected).IR (KBr, ) : 1493, 1530, 1590, 1659.

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