Authors' contributions:KA performed the experiments and data analysis, drafted the manuscript, and prepared figures.ML performed LC-MS/MS analysis, NS performed machine learning analysis and prepared figures. CP, JAW and JLB provided clinical samples, PL and AK participated in study design and manuscript editing. KC, ID and JT conceived the study, participated in its design, coordination, and data analysis, and helped write and edit the manuscript. All authors read, participated in editing the manuscript, and approved the final manuscript.