Background/purpose: The aim of the study was to compare the Efficacy and Safety of Misoprostol after 6 Hours of Mifepristone in Medical Abortions up to 7 weeks v/s 24 Hours. Material and method: The present randomized clinical trial was undertaken in the department of Obstetrics and Gynaecology at Muzaffarnagar medical college and hospital among 60 women seeking abortion up to 7 weeks (49 days). The subjects were divided into two groups i.e. group A (tablet Mifepristone 200mg orally on empty stomach and after 24hrs, 400 microgram Tablet Misoprostol given orally), group B (tablet Mifepristone 200 microgram followed by misoprostol 400 microgram after 6hours). Success was defined as complete expulsion of products of conception within 24 hours of misoprostol Failure was defined as incomplete expulsion of products of conception within 24 hrs of misoprostol. Results: Mean age of the study subjects was 24.17±5.11 years and 23.93±4.08 years in group A and group B respectively. In group A and B, mean gestation age (in weeks) was 6.37±0.77 and 6.57±0.57 respectively. Success was reported among 96.67% and 90% of the subjects in group A and B respectively with statistically insignificant difference. Conclusion:Based on the results of the present study, it can be concluded that women can use regimens with vaginal misoprostol without any time delay between medications with efficacy that is similar to those with a delay.