Purpose To compare surface properties of 2 brands of pre‐polymerized resin blocks for complete dentures (CAD/CAM PMMA) to conventional heat‐polymerized PMMA. Materials and Methods A total of 45 rectangular specimens (25 × 25 × 3 mm) were fabricated from 3 brands of PMMA (n = 15/group): AvaDent CAD/CAM PMMA, Tizian‐Schütz CAD/CAM PMMA, Meliodent conventional PMMA. Specimens were examined for wettability using the sessile drop method, surface roughness using a digital contact profilometer, and microhardness using Vickers hardness number. Statistical analysis was performed using one‐way ANOVA and Tukey pairwise multiple comparisons. p‐Values of ≤0.05 were considered significant. Results AvaDent specimens demonstrated the highest mean contact angle (72.87 ± 48°) and the highest mean Vickers hardness number (20.62 ± 0.33). The conventional heat‐polymerized specimens showed the highest mean surface roughness (0.22 ± 0.071 μm). Tizian‐Schütz specimens showed the lowest mean surface roughness (0.12 ± 0.02 μm). Conclusions As CAD/CAM PMMA groups exhibited significantly more favorable surface properties in comparison to the conventional heat‐polymerized groups, CAD/CAM dentures are expected to be more durable. Different brands of CAD/CAM PMMA may have inherent variations in surface properties.

As CAD/CAM PMMA specimens exhibited improved flexural strength, flexural modulus, and impact strength in comparison to the conventional heat-cured groups, CAD/CAM dentures are expected to be more durable. Different brands of CAD/CAM PMMA may have inherent variations in mechanical properties.