The Coronavirus Disease (COVID-19) pandemic caused by the novel virus, SARS-COV-2, has considerably increased awareness and discussions among the general populaceand scientists -regarding the important roles of vaccines. Despite the desperate need for interventions from vaccines, there is still considerable apathy and hesitancy around the acceptance and use of the available, approved vaccines in many places in Africa and Nigeria, especially. Community pharmacists are the most accessible and first points of health care for most clients. They are trusted, highly trained health care professionals. They should be incorporated and allowed to be at the forefront of reducing hesitancy in the population if the battle against COVID-19 is to be won. In this paper, we explored the extending roles of community pharmacists in building trust in the health system; proximity to the heart of deprived areas, where vaccine hesitancy predominates, and counseling education to promote the acceptance and wide coverage of COVID-19 vaccination. It is therefore recommended that the Nigerian government embrace community pharmacy-led COVID-19 vaccination initiative and embark on structured training programs for community pharmacists in addressing misconceptions about vaccinations and potentially prevent future outbreaks of vaccine-preventable diseases.

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